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Radiation therapy is the use of high-dose X-rays to destroy cancer cells. Radiation therapy may be used to treat endometrial cancer after hysterectomy or as the primary therapy, particularly for women who cannot have surgery. The two types of radiation therapy that may be used to treat endometrial cancer are:
• Internal radiation therapy (brachytherapy), in which radioactive materials (radioisotopes) are placed into the vagina, uterus, or other areas where the cancer cells are found.
• External beam radiation therapy, in which radiation comes from a machine outside the body.
In brachytherapy, tiny tubes of radioactive material are inserted into the vagina or the uterus and left in place for 2 to 3 days. Brachytherapy may be done in the hospital or as on an outpatient basis.
External beam radiation therapy is usually done in an outpatient treatment center. A typical therapy course is radiation treatments 5 days a week for 4 to 6 weeks.
Radiation therapy may cause side effects, including:
Fatigue.
Dryness, itching, tightening, and burning in the vagina.
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For long-term side effects, see the Risks section below.
Radiation therapy may make sexual intercourse uncomfortable. You may have to wait until after treatment is finished to resume sexual intercourse.
Why It Is Done
Radiation therapy is usually given after surgery (adjuvant therapy) for endometrial cancer. Adjuvant radiation may be recommended for women who have a high risk for the spread of the cancer. If a woman cannot have surgery, she may receive radiation therapy alone, but cure rates are slightly lower than with surgery.
Radiation therapy may be used at different points of treatment, depending on the stage and grade of the endometrial cancer.
Stage I: Radiation therapy is not usually used if surgery effectively removes the cancer. If cancer is found deep in the uterine muscle (myometrium), radiation of the pelvis may be given.
Stage II: Radiation therapy may be used before or after surgery. If cancer is present in the cervix, radiation may be used after surgery.
Stage III: Radiation therapy and surgery are the standard treatment options. If surgery is not recommended, radiation therapy alone may be used. Radiation therapy may also be used if more extensive cancer is discovered during surgery.
Stage IV: Radiation therapy may be used if the cancer is contained in the pelvic region but is usually not recommended if the cancer has spread (metastasized) to other parts of the body.
Endometrial cancer may recur. Radiation therapy may be used to control symptoms and increase comfort. Radiation therapy may cure your cancer if the cancer is confined to your vagina and radiation therapy has not been used before.
How Well It Works
Radiation therapy for endometrial cancer is used primarily as adjuvant therapy with surgery (hysterectomy and bilateral salpingo-oophorectomy). It is usually not recommended unless you have a high risk of cancer spreading beyond the uterus. Adjuvant radiation therapy can reduce cancer recurrence in the pelvis and vagina. 1, 2
Risks
Having radiation therapy to any part of the pelvis can cause side effects such as bladder irritation. These side effects may stop after treatment is finished.
This information is not designed to replace a physician's independent judgment about the appropriateness or risks of a procedure for a given patient.
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